Narrative:

The first officer was the pilot flying. Prior to climbing through FL410 the first officer donned his oxygen mask and was using supplemental oxygen. Approximately 20 minutes after departure at FL450 we received a cabin pressure low message on the crew alerting system. The captain immediately donned his oxygen mask and started using supplemental oxygen and then took over the flight controls from the first officer. We confirmed the validity of the message by looking at the increasingly high cabin altitude on the cabin pressure controller and initiated a rapid emergency descent with engines at idle thrust and speed brakes deployed while monitoring for other aircraft visually and on TCAS.we [advised ATC] and requested a diversion to [a nearby alternate]. We completed the checklist and QRH items. We landed without further incident.aircraft maintenance discovered that the baggage door seal would not fully inflate; and led to cabin pressure loss.

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Original NASA ASRS Text

Title: G-IV flight crew reported diverting to a nearby alternate after a malfunctioning cargo door seal led to a loss of cabin pressure.

Narrative: The First Officer was the pilot flying. Prior to climbing through FL410 the First Officer donned his oxygen mask and was using supplemental oxygen. Approximately 20 minutes after departure at FL450 we received a CABIN PRESSURE LOW message on the crew alerting system. The Captain immediately donned his oxygen mask and started using supplemental oxygen and then took over the flight controls from the First Officer. We confirmed the validity of the message by looking at the increasingly high Cabin Altitude on the CABIN PRESSURE CONTROLLER and initiated a rapid emergency descent with engines at idle thrust and speed brakes deployed while monitoring for other aircraft visually and on TCAS.We [advised ATC] and requested a diversion to [a nearby alternate]. We completed the checklist and QRH items. We landed without further incident.Aircraft Maintenance discovered that the baggage door seal would not fully inflate; and led to cabin pressure loss.

Data retrieved from NASA's ASRS site and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.