Narrative:

During climb through approximately FL250, cabin altitude warning horn sounded and cabin pressure was noted at 11000 ft and climbing. There were no other warning signals or lights. Called for leveloff and checklists. Switching initially to standby had no effect. Manual was then selected for control and to prevent masks from dropping. Coordinated with ATC for descent. Cabin was stabilized during descent as dispatch was advised. They directed return to wi. Maintenance met aircraft, troubleshot system, and MEL'ed autopressure panel. Aircraft was re-dispatched with panel configured for standby. Second flight climbing through FL230, cabin horn sounded. Switched to manual although it was noted outflow valve was closed. After a short delay in contacting center, descent was approved. Although cabin appeared to stabilize at 1200 ft, masks dropped during descent. Subsequent inspection revealed blown pressurization seal in the aft cargo compartment.

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Original NASA ASRS Text

Title: A B737-300 IN CLB AT FL250 DIVERTED DUE TO LOSS OF CABIN PRESSURE CAUSED BY A LEAKING AFT CARGO COMPARTMENT DOOR SEAL.

Narrative: DURING CLB THROUGH APPROX FL250, CABIN ALT WARNING HORN SOUNDED AND CABIN PRESSURE WAS NOTED AT 11000 FT AND CLBING. THERE WERE NO OTHER WARNING SIGNALS OR LIGHTS. CALLED FOR LEVELOFF AND CHKLISTS. SWITCHING INITIALLY TO STANDBY HAD NO EFFECT. MANUAL WAS THEN SELECTED FOR CTL AND TO PREVENT MASKS FROM DROPPING. COORDINATED WITH ATC FOR DSCNT. CABIN WAS STABILIZED DURING DSCNT AS DISPATCH WAS ADVISED. THEY DIRECTED RETURN TO WI. MAINT MET ACFT, TROUBLESHOT SYS, AND MEL'ED AUTOPRESSURE PANEL. ACFT WAS RE-DISPATCHED WITH PANEL CONFIGURED FOR STANDBY. SECOND FLT CLBING THROUGH FL230, CABIN HORN SOUNDED. SWITCHED TO MANUAL ALTHOUGH IT WAS NOTED OUTFLOW VALVE WAS CLOSED. AFTER A SHORT DELAY IN CONTACTING CTR, DSCNT WAS APPROVED. ALTHOUGH CABIN APPEARED TO STABILIZE AT 1200 FT, MASKS DROPPED DURING DSCNT. SUBSEQUENT INSPECTION REVEALED BLOWN PRESSURIZATION SEAL IN THE AFT CARGO COMPARTMENT.

Data retrieved from NASA's ASRS site as of July 2007 and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.