Narrative:

Right recirc fan and trim air deferred. Taxi out requires constant cycling of both pack temperature selectors from 'north' to 'C' to 'H' in order to balance out the temperatures. Louder than normal pack noise noted as packs operate in hi flow with a recirc fan inoperative/off. As the power is increased for taxi; the pack noise increases significantly. When the power is at idle; pack noise appears to be normal.during departure; extremely loud pack noise noted; similar to what we experienced on the ground during taxi operations. It is now difficult to hear ATC and other pilots. [We] leveled off at 3000 off runway xx. Speed window opened shortly after rotation; causing monitor pilot (me) to select cms. We leveled at 3000 and flying pilot requests speed 250. I select 250 in the speed window. Aircraft continues to accelerate. Shortly after leveling at 3000; ATC gives us 8000. Noise in cockpit [was] still very loud with packs in hi flow. Airplane continues to accelerate through 250 to 300 knots as first officer begins to pull the nose up and follow command bars for 250 knot VNAV speed climb to 8000. I call out 'airspeed' as he's well past 250 knots and doesn't seem to be correcting.all of a sudden we hear a loud 'thump;' which I would equate to a leaky door seal finally sealing. There's a noticeable pop in my ear drum and the pack noise decreases significantly to what I would consider normal levels. Pressurization panel indicates normal pressurization as we continue our climb. Established in the VNAV climb; the autothrottles still don't seem to be tracking with the airspeed (250/10000 on VNAV climb page); so the first officer engages the autopilot and begins to pull the throttles back manually in the climb. ATC gives us 10000 before we get altitude cap at 8000. Airspeed [was] stable at 250 knots and autopilot/autothrottle climb to 10000 is normal.upon arrival in ZZZ; [we] found both sidewalls at row 10 abc and def detached from the fuselage of the aircraft. Entered in mrd and advised maintenance. Not sure if the detachment is related to the 'pop' we experienced on departure.

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Original NASA ASRS Text

Title: B757 Captain reported difficulties in managing the air conditioning system; followed by a loud noise and damage to several cabin sidewall panels.

Narrative: R RECIRC Fan and Trim Air deferred. Taxi out requires constant cycling of both PACK TEMP selectors from 'N' to 'C' to 'H' in order to balance out the temperatures. Louder than normal pack noise noted as PACKS operate in HI FLOW with a RECIRC fan INOP/off. As the power is increased for taxi; the PACK noise increases significantly. When the power is at idle; PACK noise appears to be normal.During departure; extremely loud pack noise noted; similar to what we experienced on the ground during taxi operations. It is now difficult to hear ATC and other pilots. [We] leveled off at 3000 off Runway XX. Speed window opened shortly after rotation; causing monitor pilot (me) to select CMS. We leveled at 3000 and flying pilot requests SPD 250. I select 250 in the SPD window. Aircraft continues to accelerate. Shortly after leveling at 3000; ATC gives us 8000. Noise in cockpit [was] still very loud with packs in HI FLOW. Airplane continues to accelerate through 250 to 300 knots as First Officer begins to pull the nose up and follow command bars for 250 knot VNAV SPD climb to 8000. I call out 'AIRSPEED' as he's well past 250 knots and doesn't seem to be correcting.All of a sudden we hear a loud 'THUMP;' which I would equate to a leaky door seal finally sealing. There's a noticeable pop in my ear drum and the PACK noise decreases significantly to what I would consider normal levels. Pressurization panel indicates normal pressurization as we continue our climb. Established in the VNAV climb; the autothrottles still don't seem to be tracking with the airspeed (250/10000 on VNAV climb page); so the First Officer engages the autopilot and begins to pull the throttles back manually in the climb. ATC gives us 10000 before we get ALT CAP at 8000. Airspeed [was] stable at 250 knots and autopilot/autothrottle climb to 10000 is normal.Upon arrival in ZZZ; [we] found both sidewalls at row 10 ABC and DEF detached from the fuselage of the aircraft. Entered in MRD and advised Maintenance. Not sure if the detachment is related to the 'pop' we experienced on departure.

Data retrieved from NASA's ASRS site and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.