Emb-145 flight crew reported a loss of cabin pressure due to a pack 2 failure with pack 1 on MEL.

Attributes
ACN	1484531
Time
Date	201709
Local Time Of Day	1801-2400
Place
Locale Reference	ZZZ.ARTCC
State Reference	US
Environment
Light	Night
Aircraft 1
Make Model Name	EMB ERJ 145 ER/LR
Operating Under FAR Part	Part 121
Flight Phase	Descent
Flight Plan	IFR
Component
Aircraft Component	Air Conditioning and Pressurization Pack
Person 1
Function	Pilot Not Flying Captain
Qualification	Flight Crew Air Transport Pilot (ATP)
Person 2
Function	First Officer Pilot Flying
Qualification	Flight Crew Air Transport Pilot (ATP)
Events
Anomaly	Aircraft Equipment Problem Critical

Narrative:

We had pack 2 overload and fail at FL250 with pack 1 already on MEL causing the cabin to rise rapidly. We [advised ATC] to get ATC priority to 10;000 ft. We ran the associated checklists and decided ZZZ was the closest suitable airport. Landed in ZZZ.pack 2 overload with pack 1 on MEL.

Original NASA ASRS Text

Title: EMB-145 flight crew reported a loss of cabin pressure due to a PACK 2 failure with PACK 1 on MEL.

Narrative: We had PACK 2 Overload and fail at FL250 with PACK 1 already on MEL causing the cabin to rise rapidly. We [advised ATC] to get ATC priority to 10;000 ft. We ran the associated checklists and decided ZZZ was the closest suitable airport. Landed in ZZZ.PACK 2 overload with Pack 1 on MEL.

Data retrieved from NASA's ASRS site and automatically converted to unabbreviated mixed upper/lowercase text. This report is for informational purposes with no guarantee of accuracy. See NASA's ASRS site for official report.